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KMID : 0374919960170040456
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Inje Medical Journal
1996 Volume.17 No. 4 p.456 ~ p.0
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Diagnostic Efficiency of One Minute Urease Test for helicobacter Pylori
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Young Bin Jeon
M.D.
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Abstract
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Objective : There are several reliable methods for detecting Helicobacter pylori but all have as a major disadvantage the time required to yield a definitive result. Recent study indicates that the diagnosis can be made within one minute by the change of incubation condition. This study aimed to assess the diagnostic efficiency of one minute nrease test in patients with peptic ulcer treated or not treated or not treated with the agents eradicating H. pylori.
Method: In 304 patients with peptic ulcer, antral biopsies were taken for histology (Hematoxylin & Eosin staining) and one minute urease test. rebiopsies were done in 65 patients infected with H. pylori after a eradication therapy of H. pylori. The diagnostic effciency of one minute ureases test was compared with that of H&E staining.
Results: The H&E staining revealed that 237 patients (78%) of 304 patients with peptic ulcer were infected with H. pylori. Among the 65 patients given H. pylori eradication therapy, H. pylori were eradicated in 44(68%) patients. Assuming that the H&E staining is a 'gold standard', one minute urease test showed high sensitivity (88%) and specificity (85%) in the diagnosis of H. pylori infection. After eradication therapy, one minute urease test showed sensitivity of 52% and specificity of 100% in evaluating the success of eradication.
Conclusion: One minute urease test is a sensitive and specific method for the diagnosis of H. pylori infection in patients with peptic ulcer. Despite of low sensitivity for evaluation of the success of H. pylori eradication therapy, one minute urease test has the advantage that it takes low cost and short time.
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